O corpo tem seu metabolismo controlado por um relógio biológico que determina períodos de maior e menor energia, que ocorrem diretamente relacionados com o ciclo claro/escuro da luz solar. Estes ciclos são físicos, mentais e comportamentais. O mecanismo mediado pelos hormônios cortisol e melatonina, em que consiste na resposta do organismo humano aos estímulos ambientais, acompanhada pelo ciclo solar, é denominado de ritmo circadiano. O ritmo circadiano coordenado influencia no metabolismo dos nutrientes, como a ingestão dos nutrientes em certos horários impacta no ritmo circadiano. Com o entendimento desta interação mútua, que é observada tanto a nível mitocondrial, como a nível sistêmico, um hábito que deve ser aconselhado aos pacientes é a higiene do sono, que consiste em práticas como a redução da exposição à luz e a limitação da alimentação em horários próximos ao sono. Já o sono em si, é recomendado que o indivíduo durma ao menos sete horas por noite. Uma alteração do ritmo circadiano, pode levar o paciente a consequências atreladas a desregulação dos hormônios cortisol, melatonina e da metabolização de nutrientes. De modo crônico, tal quadro pode acarretar na resistência à insulina, na alteração do perfil lipídico e na maior suscetibilidade às DCNT.
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